CXC chemokine ligand 16 (CXCL16) is a CXC soluble chemokine, an adhesion molecule and a cell surface scavenger receptor. CXCL16 regulates inflammation, tissue injury and fibrosis. CXCL16 exists as a transmembrane form (TM-CXCL16) as well as a soluble form (sCXCL16) that is cleaved by proteolytic enzymes. CXCL16 is produced by several inflammatory cells including macrophages, dendritic cells, smooth muscle cells or lymphocytes. CXCL16 is expressed in various cancers, including pancreatic, prostate, breast, colorectal, and nonsmall cell lung cancer. CXCL16) has been proposed as an important pathogenic mediator in inflammatory diseases, such as rheumatoid arthritis, hepatitis or atherosclerosis.