Recombinant Human CLEC3B protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg3063
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <1.0 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human CLEC3B protein Glu22-Val202 (Accession# P05452) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 7123 |
| Accession | P05452 |
| PredictedSize | 45.7 kDa |
| SDS-PAGE | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Tetranectin, encoded by the clec3b gene, is a plasminogen kringle-4 binding protein that can be detected in the plasma and the extracellular matrix. Tetranectin originally isolated from human plasma in 1986, binds to kringle 4 of plasminogen in a lysine-dependent manner and regulates proteolytic processes via the activation of plasminogen. Tetranectin is composed of three identical and non-covalently linked 20 kDa subunits and is thought to regulate the fibrinolysis and proteolytic proceduresTetranectin was found significantly under-expressed in both serum and saliva of metastatic OSCC compared to primary OSCC.
References:
1. Xie, Xing-Wei et al. Frontiers in molecular biosciences vol. 7 (2021): 614034. 2. Liu, Jian et al. Oncology reports vol. 40,4 (2018): 2023-2035. 3. Chen, Yanjia et al. Scientific reports vol. 5 (2015) 17632. 4. Arellano-Garcia, Martha E et al. International journal of molecular sciences vol. 11,9 (2010) 3106-21.