|Cell culture supernatants||93%||80%-115%|
CD147, also called Basigin (BSG) or EMMPRIN, is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily and is important in numerous physiological and pathological phenomena. It is involved in reproduction, neural function, inflammation and tumor invasion. CD147 is broadly distributed, and expressed at particularly high levels at the retinal pigment epithelium and neonatal blood-brain barrier, on tumour cells and on activated T cells. CD147 can stimulate adjacent fibroblasts to produce matrix metalloproteinases (MMPS). It has been considered as an objective and effective marker to predict invasion and prognosis in various cancers. Soluble CD147 (sCD147) has been uncovered in addition to membrane-bound CD147. sCD147 production is mediated by two different mechanisms: microvesicular secretion and proteolytic cleavage. The presence of sCD147 in body fluids is associated with several diseases such as systemic sclerosis, hepatocellular carcinoma, ankylosing spondylitis and coronary diseases.