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×
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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0
×

Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

Purchase

Recombinant Human C-Reactive Protein protein (rFc Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg2448

Validation Data Gallery

  • Purity of Recombinant Human C-Reactive Protein was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Human C-Reactive Protein was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human C-Reactive Protein protein Gln19-Pro224 (Accession# P02741-1) with a rabbit IgG Fc tag at the C-terminus.
GeneID 1401
Accession P02741-1
PredictedSize 49.3 kDa
SDS-PAGE 47-53 kDa, reducing (R) conditions
Formulation Lyophilized from sterile 20 mM Tris, 1 M Nacl, pH 8.0. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

C-reactive protein (CRP) is an acute-phase serum protein synthesized by the liver in response to interleukin-6 (IL-6) during inflammation. The name of CRP derives from its ability to react with the C polysaccharide of Streptococcus pneumoniae. CRP is an annular, pentameric protein that belongs to the pentraxin family of proteins. CRP displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. It is used mainly as a marker of inflammation.

References:

1. Rizo-Téllez, Salma A et al. Frontiers in immunology vol. 14 1237729. 26 Jul. 2023.
2. Black, Steven et al. The Journal of biological chemistry vol. 279,47 (2004): 48487-90.
3. Zhou, Hai-Hong et al. Frontiers in immunology vol. 15 1425168. 14 Jun. 2024.