Speedy™ Human BCMA/TNFRSF17 One-Step ELISA Kit
Sensitivity
1.3 pg/mL
Range
31.25-2000 pg/mL
Reactivity
Human
Cat no : SE50071
Synonyms
TNFRSF17, B-cell maturation protein, BCM, BCMA, CD269
Validation Data Gallery
Product Information
| Product name | Speedy™ Human BCMA/TNFRSF17 One-Step ELISA Kit |
| Tests | 1 X 96 well plate |
| Sample type | Serum, Plasma, Urine, Saliva |
| Assay type | Sandwich |
| Sensitivity | 1.3 pg/mL |
| Range | 31.25-2000 pg/mL |
| Reactivity | Human |
| Tested applications | Sandwich ELISA |
| Gene ID (NCBI) | 608 |
Recovery
| Sample Type | Average | Range |
|---|---|---|
| Human plasma | 108% | 104%-115% |
| Urine | 117% | 114%-119% |
| Saliva | 94% | 91%-96% |
IntraAssay
| Sample | n | mean ( pg/mL) | SD | CV% |
|---|---|---|---|---|
| 1 | 8 | 1,041.9 | 35.3 | 3.4 |
| 2 | 8 | 250.1 | 2.6 | 1.0 |
| 3 | 8 | 126.2 | 1.8 | 1.4 |
InterAssay
| Sample | n | mean ( pg/mL) | SD | CV% |
|---|---|---|---|---|
| 1 | 16 | 1,035.2 | 35.6 | 3.4 |
| 2 | 16 | 252.3 | 4.5 | 1.8 |
| 3 | 16 | 126.5 | 2.2 | 1.7 |
Background Information
BCMA (B cell maturation antigen), also known as TNFRSF17, is a type III transmembrane glycoprotein and is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes and plasma cells, which may be important for B cell development and autoimmune response. BCMA has two agonist ligands: a proliferation-inducing ligand (APRIL) and BAFF. When BCMA binds to APRIL, it transmits signals of cell survival and proliferation; when BCMA binds to BAFF, it mediates the activation of NF-kappaB and MAPK8/JNK. It has been found that the overexpression and activation of BCMA are associated with multiple myeloma (MM) in preclinical models and humans, supporting its potential utility as a therapeutic target for MM.
Properties
| Storage Instructions | All the reagents are stored at 2-8℃ for 6 months or -20℃ for 12 months. Refer to the protocol for further storage instructions. |
| Synonyms | TNFRSF17, B-cell maturation protein, BCM, BCMA, CD269 |