Recombinant human B7-H6 protein (Myc Tag, His Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
Myc Tag, His Tag
Activity
not tested
Cat no : Eg0007
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <1.0 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human B7-H6 protein Asn25-Ser262 (Accession# Q68D85) with a Myc tag and a His tag at the C-terminus. |
| GeneID | 374383 |
| Accession | Q68D85 |
| PredictedSize | 32.3 kDa |
| SDS-PAGE | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
B7-H6, also known as NCR3LG1, is a co-stimulatory ligand that plays a crucial role in the immune response by binding to the natural killer (NK) cell activating receptor NKp30. It was reported that B7-H6 has inhibitory effects on cell proliferation and migration. It is primarily localized in the cell membrane of tumor cells, where it can interact with NKp30 on NK cells. In some cases, B7-H6 can also be found in the intracellular space of cancer cells, such as in small cell lung cancer (SCLC).
References:
1.Mohammadi, Alaleh et al. Life sciences vol. 304, (2022): 120709. 2.Brandt, Cameron S et al. The Journal of experimental medicine vol. 206,7 (2009): 1495-503. 3.Zhang, Xiuqin et al. Annals of translational medicine vol. 8,9 (2020): 589. Banu, Nehla et al. BMC cancer vol. 20,1 (2020): 1083.