|Cell culture supernatants||88%||76%-104%|
B7-H3 (CD276) is a type I transmembrane protein expressed on many tissues and cell types. B7-H3 is a 100-kDa glycoprotein that belongs to the B7 immunoregulatory family and participates in the regulation of T-cell-mediated immune response probably by functioning as both a T cell costimulator and coinhibitor. Overexpressed on a wide range of human solid cancers, B7-H3 has been implicated in cancer progression and metastasis and becomes an attractive target for cancer immunotherapy. Soluble form of B7-H3 (sB7-H3), released by monocytes, dendritic cells, activated T cells, and B7-H3-positive tumor cells, has been detected in human blood samples and cell culture supernatants.