Recombinant Human Zinc Alpha 2 Glycoprotein protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg6736
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human Zinc Alpha 2 Glycoprotein protein Gln21-Ser298 (Accession# P25311) with a rabbit IgG Fc tag at the N-terminus. |
| GeneID | 563 |
| Accession | P25311 |
| PredictedSize | 59.3 kDa |
| SDS-PAGE | 60-75 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Zinc-alpha-2-glycoprotein (AZGP1) is a 41-kDa soluble protein normally found in body fluids, functions as a lipid mobilizing factor. It is known to be expressed in the secretory epithelia of the liver, lung, breast, GI tract and sweat glands, sharing significant structural similarity with the class I major histocompatibility complex (MHC) antigens. AZGP1 is involved in carcinogenesis and differentiation. Altered expression of AZGP1 has been reported in breast cancer, prostate cancer and lung adenocarcinoma, hepatocellular carcinoma, pancreatic carcinoma and oral tumors.
References:
1.Vanni, Holly et al. Chest vol. 135,5 (2009): 1197-1208. 2.Araki, T et al. Proceedings of the National Academy of Sciences of the United States of America vol. 85,3 (1988): 679-83. 3.Huang, Yan et al. Journal of translational medicine vol. 10 106. 24 May. 2012
