Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
51060-1-PBS targets Hepsin in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
Peptide 相同性解析による交差性が予測される生物種 |
| Full Name | hepsin |
| Calculated molecular weight | 47 kDa |
| Observed molecular weight | 28 kDa |
| GenBank accession number | BC138809 |
| Gene Symbol | Hepsin |
| Gene ID (NCBI) | 15451 |
| RRID | AB_763181 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | O35453 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
Hepsin is a type II transmembrane serine protease. It is primarily expressed in the liver but has also been detected in other tissues, including the prostate, kidney, and pancreas. Hepsin plays a crucial role in various physiological processes, such as cell growth, extracellular matrix remodeling, and tissue homeostasis. Notably, Hepsin has been implicated in cancer progression, particularly in prostate cancer, where its overexpression is associated with tumor metastasis and poor prognosis (PMID: 15324701, PMID: 18726901). Hepsin has been identified as a peptide of approximately 45 kDa representing the intact protein, and a fragment of about 28 kDa representing the cleaved extracellular domain (PMID: 19302215, PMID: 21734266).