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Validation Data Gallery

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  • Western Blot (WB) analysis of L02 cells using HPSE2 Polyclonal antibody (21128-1-AP)

    WB analysis of L02 using 21128-1-AP

    L02 cells were subjected to SDS PAGE followed by western blot with 21128-1-AP (HPSE2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

  • Western Blot (WB) analysis of L02 cells using HPSE2 Polyclonal antibody (21128-1-AP)

    WB analysis of L02 using 21128-1-AP

    L02 cells were subjected to SDS PAGE followed by western blot with 21128-1-AP (HPSE2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

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HPSE2 Polyclonal antibody

HPSE2 Polyclonal Antibody for WB, ELISA
Cat No. 21128-1-AP
Publications(1)

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IF, ELISA

Synonyms

heparanase 2, Hpa2, HPR2, Inactive heparanase-2

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Positive WB detected inL02 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

21128-1-AP targets HPSE2 in WB, IF, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivityhuman
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen HPSE2 fusion protein Ag15526 相同性解析による交差性が予測される生物種
Full Name heparanase 2
Calculated molecular weight 592 aa, 67 kDa
Observed molecular weight 54 kDa, 66 kDa
GenBank accession numberBC112356
Gene Symbol HPSE2
Gene ID (NCBI) 60495
RRIDAB_10733344
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ8WWQ2
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

HPSE2 (heparanase 2) is a homolog of HPSE (heparanase 1). HPSE is an endo-β-glucuronidase that cleaves heparan sulfate proteoglycans (HSPGs), which are important components of the extracellular matrix and basement membranes. HPSE2, however, lacks intrinsic heparan sulfate-degrading activity. Instead, it binds to heparan sulfate with higher affinity than HPSE, thereby competing with HPSE for heparan sulfate binding and inhibiting HPSE's enzymatic activity. This competitive inhibition makes HPSE2 a crucial regulator of heparan sulfate metabolism.

Protocols

Product Specific Protocols
WB protocol for HPSE2 antibody 21128-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB,IF

Viruses

Heparanase 2 Modulation Inhibits HSV-2 Replication by Regulating Heparan Sulfate

Authors - James Hopkins
View Article