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Validation Data Gallery

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  • Western Blot (WB) analysis of human placenta tissue using HLX Polyclonal antibody (14336-1-AP)

    WB analysis of human placenta using 14336-1-AP (same clone as 14336-1-PBS)

    human placenta tissue were subjected to SDS PAGE followed by western blot with 14336-1-AP (HLX antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14336-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human endometrial cancer tissue using HLX Polyclonal antibody (14336-1-AP)

    IHC staining of human endometrial cancer using 14336-1-AP (same clone as 14336-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human endometrial cancer using 14336-1-AP (HLX antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 14336-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human endometrial cancer tissue using HLX Polyclonal antibody (14336-1-AP)

    IHC staining of human endometrial cancer using 14336-1-AP (same clone as 14336-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human endometrial cancer using 14336-1-AP (HLX antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 14336-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of A549 cells using HLX Polyclonal antibody (14336-1-AP)

    IF Staining of A549 using 14336-1-AP (same clone as 14336-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed A549 cells using 14336-1-AP (HLX antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 14336-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

HLX Polyclonal antibody, PBS Only

HLX Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 14336-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, IF/ICC, Indirect ELISA

Synonyms

Formulation:  PBS Only
PBS, Azide, Glycerol
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

14336-1-PBS targets HLX in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag5627

Product name: Recombinant human HLX protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 134-488 aa of BC033808

Sequence: QQQQPPPPPRAGALQPPASGTRVVPNPHHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPAGVHLSGLQPSAGQFFASLDPINEASAILSPLNSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGAPAADGEQDERSPSRSEGEAESESSDSESLDMAPSDTERTEGSERSLHQTTVIKAPVTGALITASSAGSGGSSGGGGNSFSFSSASSLSSSSTSAGCASSLGGGGASELLPATQPTASSAPKSPEPAQGALGCL

相同性解析による交差性が予測される生物種
Full Name H2.0-like homeobox
Calculated molecular weight 51 kDa
Observed molecular weight 51 kDa
GenBank accession numberBC033808
Gene Symbol HLX
Gene ID (NCBI) 3142
RRIDAB_2232971
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDQ14774
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

In immune system, Hlx is a Th1-special transcription factor that interacts specifically with T-bet, and synergistically they promote IFN-γ expression when co-expressed. It can down-regulate the IL-4 receptor expression in naive CD4+ T cells [PMID:14688316]. Over expression of Hlx contributes ot the aberrant expression of IFN-γ in normal CD4+ T cells during the differentiation under Th2-polarizing conditions. In addition, Hlx is a negative regulator of IFN-γ production in NK cells and its inhibitory function is achieved at least in part through the proteasomal degradation of STAT4 [PMID:16424184].

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