HKDC1 (Hexokinase Domain Containing 1), encodes a 917-amino-acid protein with a molecular weight of approximately 102.5 kDa (102,545 Da). The protein is widely expressed, with higher expression in tissues such as the duodenum, small intestine, kidney, and colon, and primarily localizes to the cytoplasm and mitochondria. HKDC1 functions as a hexokinase that catalyzes the phosphorylation of hexose sugars, albeit at very low levels compared to other hexokinases. It plays a role in glucose metabolism and homeostasis, and is required to maintain whole-body glucose homeostasis during pregnancy. Additionally, HKDC1 is involved in coordinating mitochondrial and lysosomal homeostasis, which is critical for preventing cellular senescence.