Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
17954-1-PBS targets HFE in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag12448 Product name: Recombinant human HFE protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 29-295 aa of BC074721 Sequence: SLHYLFMGASEQDLGLSLFEALGYVDDQLFVFYDHESRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQVILGCEMQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRARQNRAYLERDCPAQLQQLLELGRGVLDQQEGSESSSLPGKVTTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWE 相同性解析による交差性が予測される生物種 |
| Full Name | hemochromatosis |
| Calculated molecular weight | 345 aa, 40 kDa |
| Observed molecular weight | 45-58 kDa |
| GenBank accession number | BC074721 |
| Gene Symbol | HFE |
| Gene ID (NCBI) | 3077 |
| RRID | AB_10596779 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q30201 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
HFE is an important iron metabolism regulatory protein, which regulates the production of hepcidin through interactions with other proteins such as transferrin receptor 1 (TfR1) and TfR2. HFE is the most common pathogenic gene for hereditary hemochromatosis, which is a hereditary disease of iron accumulation in multiple organs caused by mutations in genes regulating iron metabolism.