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Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
87729-1-PBS targets GRM5 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
Peptide 相同性解析による交差性が予測される生物種 |
| Full Name | glutamate receptor, metabotropic 5 |
| Calculated molecular weight | 132 kDa |
| Observed molecular weight | 120 kDa |
| GenBank accession number | NM_000842 |
| Gene Symbol | GRM5 |
| Gene ID (NCBI) | 2915 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P41594 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
GRM5 (mGluR5) is a group I class C GPCR that couples to Gq/PLCβ signaling to regulate postsynaptic glutamatergic transmission, calcium signaling, and synaptic plasticity. Highly enriched in cortical, hippocampal, and striatal neurons, GRM5 is a key modulator of learning, memory, excitability, and neurobehavioral circuit function. Dysregulation of GRM5 signaling has been implicated in fragile X syndrome, autism-related disorders, neuropsychiatric disease, chronic pain, and neurodegeneration, making it a major target in CNS drug discovery.