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Validation Data Gallery

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  • Western Blot (WB) analysis of pig bone marrow tissue using GDF10 Monoclonal antibody (66371-1-Ig)

    WB analysis of pig bone marrow using 66371-1-Ig (same clone as 66371-1-PBS)

    pig bone marrow tissue were subjected to SDS PAGE followed by western blot with 66371-1-Ig (GDF10 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66371-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of ROS1728 cells using GDF10 Monoclonal antibody (66371-1-Ig)

    WB analysis of ROS1728 using 66371-1-Ig (same clone as 66371-1-PBS)

    ROS1728 cells were subjected to SDS PAGE followed by western blot with 66371-1-Ig (GDF10 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66371-1-PBS in a different storage buffer formulation.

GDF10 Monoclonal antibody, PBS Only

GDF10 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 66371-1-PBS
Clone No.1B7D12

Host / Isotype

Mouse / IgG2a

Reactivity

human, pig, rat

Applications

WB, Indirect ELISA

Synonyms

BIP, BMP 3b, BMP3B, Bone inducing protein, Bone morphogenetic protein 3B, GDF 10, GDF10

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

66371-1-PBS targets GDF10 in WB, Indirect ELISA applications and shows reactivity with human, pig, rat samples.

Tested Reactivity human, pig, rat
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen

CatNo: Ag4906

Product name: Recombinant human GDF10 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-288 aa of BC028237

Sequence: MALAPPPRGLWQAKDISPIVKAARRDGELLLSAQLDSEERDPGVPRPSPYAPYILVYANDLAISEPNSVAVTLQRYDPFPAGDPEPRAAPNNSADPRVRRAAQATGPLQDNELPGLDERPPRAHAQHFHKHQLWPSPFRALKPRPGRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR

相同性解析による交差性が予測される生物種
Full Name growth differentiation factor 10
Calculated molecular weight 53 kDa
Observed molecular weight 53 kDa
GenBank accession numberBC028237
Gene Symbol GDF10
Gene ID (NCBI) 2662
RRIDAB_2881750
Conjugate Unconjugated
Form
FormLiquid
Purification MethodProtein A purification
UNIPROT IDP55107
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

Growth differentiation factor-10 (GDF10), also known as BMP3b, is a member of the transforming growth factor-b (TGF-b) superfamily. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. GDF10 plays a role in head formation and may have multiple roles in skeletal morphogenesis. Additionally, GDF10 may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer.