Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
87975-1-PBS targets Frizzled 4 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
CatNo: Eg5015 Product name: Recombinant human FZD4 protein Source: mammalian cells-derived, pHZ-KIsec-C-mFc Tag: C-mFc Domain: 37-180 aa of BC114527 Sequence: FGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEE 相同性解析による交差性が予測される生物種 |
| Full Name | frizzled homolog 4 (Drosophila) |
| Observed molecular weight | 60 kDa |
| GenBank accession number | BC114527 |
| Gene Symbol | FZD4 |
| Gene ID (NCBI) | 8322 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q9ULV1 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
Frizzled 4, officially known as frizzled class receptor 4 and designated FZD4, is a protein encoded by the FZD4 gene in humans. It is a member of the frizzled (Fz) gene family, which encodes seven-transmembrane domain proteins that primarily function as receptors for Wnt signaling proteins. Frizzled 4 is embedded in the outer membrane of many cell types, where it plays a critical role in transmitting chemical signals from outside the cell to the nucleus. Frizzled 4 has an almost ubiquitous expression pattern and is found in a wide range of human tissues. Mutations in the FZD4 gene are linked to familial exudative vitreoretinopathy (EVR1), an eye disorder that affects the retina and can lead to progressive vision loss.