Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
24321-1-PBS targets FXI in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag18004 Product name: Recombinant human F11 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 58-397 aa of BC119014 Sequence: LFTFTAESPSEDPTRWFTCVLKDSVTETLPRVNRTAAISGYSFKQCSHQISACNKDIYVDLDMKGINYNSSVAKSAQECQERCTDDVHCHFFTYATRQFPSLEHRNICLLKHTQTGTPTRITKLDKVVSGFSLKSCALSNLACIRDIFPNTVFADSNIDSVMAPDAFVCGRICTHHPGCLFFTFFSQEWPKESQRNLCLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRG 相同性解析による交差性が予測される生物種 |
| Full Name | coagulation factor XI |
| Calculated molecular weight | 625 aa, 70 kDa |
| Observed molecular weight | 70 kDa |
| GenBank accession number | BC119014 |
| Gene Symbol | F11 |
| Gene ID (NCBI) | 2160 |
| RRID | AB_3742107 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P03951 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
Factor XI (FXI) is the zymogen of a blood coagulation protease, factor XIa (FXIa), that contributes to hemostasis by activating factor IX. Factor XI is a precursor of an S1 serine protease found in blood plasma. When activated to FXIa, it plays a crucial role in forming and stabilizing fibrin by triggering the activation of factor IX (PMID: 38545505). FXI has 2 isoforms with the molecular mass of 70 kDa and 64 kDa. Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.