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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using FUNDC2 Polyclonal antibody (19832-1-AP)

    WB analysis using 19832-1-AP (same clone as 19832-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 19832-1-AP (FUNDC2 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 19832-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HuH-7 cells using FUNDC2 Polyclonal antibody (19832-1-AP)

    WB analysis of HuH-7 using 19832-1-AP (same clone as 19832-1-PBS)

    HuH-7 cells were subjected to SDS PAGE followed by western blot with 19832-1-AP (FUNDC2 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 19832-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human stomach cancer tissue using FUNDC2 Polyclonal antibody (19832-1-AP)

    IHC staining of human stomach cancer using 19832-1-AP (same clone as 19832-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 19832-1-AP (FUNDC2 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19832-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human stomach cancer tissue using FUNDC2 Polyclonal antibody (19832-1-AP)

    IHC staining of human stomach cancer using 19832-1-AP (same clone as 19832-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 19832-1-AP (FUNDC2 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19832-1-PBS in a different storage buffer formulation.

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FUNDC2 Polyclonal antibody, PBS Only

FUNDC2 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 19832-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Synonyms

HCC 3, HCBP6, FUN14 domain-containing protein 2, FUN14 domain containing 2, DC44

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

19832-1-PBS targets FUNDC2 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen FUNDC2 fusion protein Ag13800 相同性解析による交差性が予測される生物種
Full Name FUN14 domain containing 2
Calculated molecular weight 189 aa, 21 kDa
Observed molecular weight21 kDa
GenBank accession numberBC000255
Gene Symbol FUNDC2
Gene ID (NCBI) 65991
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9BWH2
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

FUNDC2, or FUN14 domain-containing protein 2, is a mitochondrial outer membrane protein that plays a significant role in various cellular processes, including the regulation of cell survival, apoptosis, and metabolism. It has been implicated in the progression of several types of cancer, particularly in triple-negative breast cancer (TNBC) and liver cancer. In the context of cancer, FUNDC2 has been shown to promote tumorigenesis. It is associated with poor prognosis in hepatocellular carcinoma (HCC) and is involved in mitochondrial fragmentation by inhibiting MFN1-mediated mitochondrial fusion, which can lead to changes in cellular metabolism and energy levels. FUNDC2 also plays a role in platelet function and survival. It binds directly to phosphatidylinositol-3,4,5-trisphosphate (PIP3), which is a key lipid second messenger in cell signaling, and this interaction is crucial for the recruitment of PIP3 to mitochondria. FUNDC2 deficiency has been shown to decrease platelet aggregation and impair hemostasis in mice, highlighting its importance in platelet function.