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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using FBXW11 Polyclonal antibody (13149-1-AP)

    WB analysis using 13149-1-AP (same clone as 13149-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 13149-1-AP (FBXW11 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13149-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using FBXW11 Polyclonal antibody (13149-1-AP)

    WB analysis using 13149-1-AP (same clone as 13149-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 13149-1-AP (FBXW11 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13149-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of SGC-7901 cells using FBXW11 Polyclonal antibody (13149-1-AP)

    WB analysis of SGC-7901 using 13149-1-AP (same clone as 13149-1-PBS)

    SGC-7901 cells were subjected to SDS PAGE followed by western blot with 13149-1-AP (FBXW11 Antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13149-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using FBXW11 Polyclonal antibody (13149-1-AP)

    WB analysis using 13149-1-AP (same clone as 13149-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 13149-1-AP (FBXW11 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13149-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of SGC-7901 cells using FBXW11 Polyclonal antibody (13149-1-AP)

    WB analysis of SGC-7901 using 13149-1-AP (same clone as 13149-1-PBS)

    SGC-7901 cells were subjected to SDS PAGE followed by western blot with 13149-1-AP (FBXW11 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13149-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of human stomach tissue using FBXW11 Polyclonal antibody (13149-1-AP)

    WB analysis of human stomach using 13149-1-AP (same clone as 13149-1-PBS)

    human stomach tissue were subjected to SDS PAGE followed by western blot with 13149-1-AP (FBXW11 antibody) at dilution of 1:0 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13149-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using FBXW11 Polyclonal antibody (13149-1-AP)

    WB analysis using 13149-1-AP (same clone as 13149-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 13149-1-AP (FBXW11 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13149-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human stomach cancer tissue using FBXW11 Polyclonal antibody (13149-1-AP)

    IHC staining of human stomach cancer using 13149-1-AP (same clone as 13149-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 13149-1-AP (FBXW11 Antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 13149-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human stomach cancer tissue using FBXW11 Polyclonal antibody (13149-1-AP)

    IHC staining of human stomach cancer using 13149-1-AP (same clone as 13149-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 13149-1-AP (FBXW11 Antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 13149-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HCT 116 cells using FBXW11 Polyclonal antibody (13149-1-AP)

    IF Staining of HCT 116 using 13149-1-AP (same clone as 13149-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HCT 116 cells using FBXW11 antibody (13149-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L), CL594-Phalloidin (red). This data was developed using the same antibody clone with 13149-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of A431 cells using FBXW11 Polyclonal antibody (13149-1-AP)

    IF Staining of A431 using 13149-1-AP (same clone as 13149-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed A431 cells using FBXW11 antibody (13149-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 13149-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of U2OS cells using FBXW11 Polyclonal antibody (13149-1-AP)

    IF Staining of U2OS using 13149-1-AP (same clone as 13149-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed U2OS cells using FBXW11 antibody (13149-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 13149-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

FBXW11 Polyclonal antibody, PBS Only

FBXW11 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Cat No. 13149-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, IF/ICC, Indirect ELISA

Synonyms

Formulation:  PBS Only
PBS, Azide, Glycerol
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

13149-1-PBS targets FBXW11 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag3761

Product name: Recombinant human FBXW11 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 216-529 aa of BC026213

Sequence: NLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR

相同性解析による交差性が予測される生物種
Full Name F-box and WD repeat domain containing 11
Calculated molecular weight 542 aa, 61 kDa
Observed molecular weight 61 kDa
GenBank accession numberBC026213
Gene Symbol FBXW11
Gene ID (NCBI) 23291
RRIDAB_2102595
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9UKB1
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

FBXW11 (also known as HOS or β-TrCP2) is a member of F-box family proteins and plays critical role in regulating the ubiquitination of phosphorylated substrates. Abnormal expression of several FBXW11 is involved in the modulation of various biological events, such as cell cycle, differentiation, migration, inflammation, and apoptosis, through targeting multiple different substrates. For instance, FBXW11 could bind to the phosphorylated IκB and β-catenin, promoting their degradation via the ubiquitin-proteasome system. In addition, FBXW11 expression is markedly increased in mouse skin tumors and promotes tumor growth by activating the NF-κB signaling (PMID: 33640602). FBXW11 has 3 isoforms with the molecular mass of 58-62 kDa.

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