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Validation Data Gallery

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  • Immunoprecipitation (IP) experiment of HeLa cells using FBX4 Polyclonal antibody (13855-1-AP)

    IP experiment of HeLa using 13855-1-AP

    IP result of anti-FBX4 (IP:13855-1-AP, 4ug; Detection:13855-1-AP 1:800) with HeLa cells lysate 1400 ug.

  • Immunoprecipitation (IP) experiment of A431 cells using FBX4 Polyclonal antibody (13855-1-AP)

    IP experiment of A431 using 13855-1-AP

    IP result of anti-FBX4 (IP:13855-1-AP, 4ug; Detection:13855-1-AP 1:800) with A431 cells lysate 1040 ug.

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FBX4 Polyclonal antibody

FBX4 Polyclonal Antibody for IP, ELISA
Cat No. 13855-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IP, ELISA

Synonyms

FBXO4, F-box only protein 4, F box protein 4, F box only protein 4

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Positive IP detected inHeLa cells, A431 cells

Recommended dilution

ApplicationDilution
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

13855-1-AP targets FBX4 in IP, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen FBX4 fusion protein Ag4829 相同性解析による交差性が予測される生物種
Full Name F-box protein 4
Calculated molecular weight 44 kDa
Observed molecular weight38 kDa
GenBank accession numberBC048098
Gene Symbol FBXO4/FBX4
Gene ID (NCBI) 26272
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9UKT5
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

FBX4 (F-Box Protein 4), also known as FBXO4, is a member of the F-box protein family. FBX4 is involved in the ubiquitination of various target proteins, leading to their degradation. It has been shown to regulate the cell cycle by targeting proteins such as cyclin D1 for ubiquitination and degradation. Mutations in FBX4 have been linked to various diseases, including spermatogenic failure and esophageal cancer. In cancer, FBX4 has been shown to act as a tumor suppressor. Loss of FBX4 function can lead to increased cell proliferation and tumor development. For example, FBX4 knockout mice have been shown to develop various tumors, including lymphoblastic lymphoma and mammary carcinoma.

Protocols

Product Specific Protocols
IP protocol for FBX4 antibody 13855-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols