Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
33208-1-PBS targets FAM21A in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag36997 Product name: Recombinant human FAM21A protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1100-1341 aa of BC082258 Sequence: AAPWEGGPVPGVDRSPFAKSLGHSRGEADLFDSGDIFSTGTGSQSVERTKPKAKIAENPANPPVGGKAKSPMFPALGEASSDDDLFQSAKPKPAKKTNPFPLLEDEDDLFTDQKVKKNETKSNSQQDVILTTQDIFEDDIFATEAIKPSQKTREKEKTLESNLFDDNIDIFADLTVKPKEKSKKKVEAKSIFDDDMDDIFSSGIQAKTTKPKSRSAQAAPEPRFEHKVSNIFDDPLNAFGGQ 相同性解析による交差性が予測される生物種 |
| Full Name | family with sequence similarity 21, member A |
| Observed molecular weight | 170 kDa |
| GenBank accession number | BC082258 |
| Gene Symbol | FAM21A |
| Gene ID (NCBI) | 387680 |
| RRID | AB_3742896 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q641Q2 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
The FAM21A protein, full name Family with sequence similarity 21 member A, belongs to the FAM21 protein family. This protein is a core subunit of the WASH complex (Wiskott-Aldrich syndrome protein and SCAR homolog complex) and plays a critical role in endosomal sorting and membrane trafficking. Its primary function is to recruit the WASH complex to the endosomal membrane surface by binding to phospholipids (such as phosphatidylinositol 4-phosphate) and the VPS35 subunit of the Retromer complex, thereby anchoring the complex to the correct position on the endosomal membrane.