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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using EPS8L3 Polyclonal antibody (32571-1-AP)

    WB analysis using 32571-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 32571-1-AP (EPS8L3 antibody) at dilution of 1:40000 incubated at room temperature for 1.5 hours.

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EPS8L3 Polyclonal antibody

EPS8L3 Polyclonal Antibody for WB, ELISA
Cat No. 32571-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

Epidermal growth factor receptor kinase substrate 8-like protein 3, Epidermal growth factor receptor pathway substrate 8-related protein 3, EPS8 Signaling Adaptor L3, EPS8-like protein 3, EPS8R3

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

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テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Positive WB detected inHepG2 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:5000-1:50000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

32571-1-AP targets EPS8L3 in WB, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen EPS8L3 fusion protein Ag38525 相同性解析による交差性が予測される生物種
Full Name EPS8-like 3
Calculated molecular weight67kDa，593aa
Observed molecular weight65 kDa
GenBank accession numberNM_001319952.1
Gene Symbol EPS8L3
Gene ID (NCBI) 79574
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity Purification
UNIPROT IDQ8TE67
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

EPS8L3 (epidermal growth factor receptor kinase substrate 8-like protein 3) is a member of the EPS8 family, encoding a protein associated with the epidermal growth factor receptor (EGFR) signaling pathway. Studies have shown that EPS8L3 is highly expressed in a variety of tumors, such as hepatocellular carcinoma (HCC), pancreatic cancer, and gastric cancer, and is closely associated with tumor proliferation, migration, and invasive ability. It promotes tumor cell proliferation and inhibits apoptosis by activating GSK3β and PI3K/AKT/mTOR signaling pathways. In addition, high expression of EPS8L3 is associated with poor prognosis in tumor patients and may serve as a biomarker for tumor diagnosis and prognostic assessment. Due to its important role in tumors, EPS8L3 is considered a potential therapeutic target, and its inhibition may enhance the efficacy of multi-target kinase inhibitors.

Protocols

Product Specific Protocols
WB protocol for EPS8L3 antibody 32571-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols