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ENDOG Recombinant antibody

ENDOG Uni-rAbTM Recombinant Antibody for WB, ELISA
Cat No. 86122-1-RR
Clone No.250804D2

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

EC:3.1.30.-, Endo G, Endonuclease G

Formulation:  PBS and Azide
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -


ご購入について

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国内在庫・納期について

約2万点のプロテインテック製品をコスモバイオ社物流センター(国内)に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。


保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換/補填対応を承ります。詳細はこちらをご覧ください。


Tested Applications

Positive WB detected inNIH/3T3 cells, HeLa cells, mouse heart tissue, mouse liver tissue, rat liver tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:6000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

86122-1-RR targets ENDOG in applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen ENDOG fusion protein Ag17739 相同性解析による交差性が予測される生物種
Full Name endonuclease G
Calculated molecular weight 297 aa, 33 kDa
Observed molecular weight 25-30 kDa
GenBank accession numberBC016351
Gene Symbol ENDOG
Gene ID (NCBI) 2021
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ14249
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Endonuclease G, also named as EndoG, is a mitochondrial protein. It's a nuclease which was first characterized in bovine heart mitochondrial extracts. It's involved in many cellular process, including apoptosis, paternal mitochondrial elimination and autophage (PMID:33473107). It is a nuclear encoded, sugar-non-specific (PMID:15066427) and well-conserved nuclease (PMID:17244531). It can be released from the mitochondria and translocated to the nucleus where it induces fragmentation of DNA, leading to apoptosis (PMID:11452314). EndoG is a 297-amino-acid long protein with a molecular weight of 30-35 kDa. There is a homodimer form with MW about 60-70 kDa.

Protocols

Product Specific Protocols
WB protocol for ENDOG antibody 86122-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols
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