Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
24054-1-PBS targets CNKSR2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag21183 Product name: Recombinant human CNKSR2 protein Source: e coli.-derived, PET30a Tag: 6*His Domain: 400-558 aa of BC126121 Sequence: RKRFNIVEEDTVLYCYEYEKGRSSSQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRRENSLLRYMSNEKIAQEEYMFQRNSKKDTGKKSKKKGDKSNSPTHYSLLPSLQMDALRQDIMGTPVPETTLYHTFQQSSLQHKSKKKNKGPIAGK 相同性解析による交差性が予測される生物種 |
| Full Name | connector enhancer of kinase suppressor of Ras 2 |
| Calculated molecular weight | 1034 aa, 118 kDa |
| Observed molecular weight | 110 kDa, 130 kDa |
| GenBank accession number | BC126121 |
| Gene Symbol | CNKSR2 |
| Gene ID (NCBI) | 22866 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Antigen Affinity purified |
| UNIPROT ID | Q8WXI2 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
The Connector Enhancer of Kinase Suppressor of Ras-2 (CNKSR2), also known as CNK2 or MAGUIN, KIAA0902 and KSR2, is a scaffolding molecule that contains functional protein binding domains (PMID: 35053419). CNKSR2 interacts with different molecules, including RAF1, ARHGAP39, and CYTH2, and regulates the Mitogen-Activated Protein Kinase (MAPK) cascade and small GTPase signaling (PMID: 35053419). The study identify a molecular complex comprising CNKSR2 and the guanine nucleotide exchange factor (GEF) for ARF small GTPases, CYTH2, that is necessary for the proper development of granule neurons in the mouse hippocampus (PMID: 34800437). CNKSR2 plays a key role in regulating cell proliferation, and differentiation through multiple receptor tyrosine kinase pathways (PMID: 35053419). The molecular weight of CNKSR2 is mainly 117 kDa (PMID: 29534682). It has also been reported that CNKSR2 immunoblotted signal of about 110 kDa was detected, while a 130 kDa signal was detected (PMID: 34800437).