• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0
×

Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

Use Able AI chat for product recommendations

Validation Data Gallery

Filter:
  • Western Blot (WB) analysis of various lysates using CLK1 Polyclonal antibody (20439-1-AP)

    WB analysis using 20439-1-AP (same clone as 20439-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 20439-1-AP (CLK1 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20439-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using CLK1 Polyclonal antibody (20439-1-AP)

    WB analysis using 20439-1-AP (same clone as 20439-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 20439-1-AP (CLK1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20439-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of HeLa cells using CLK1 Polyclonal antibody (20439-1-AP)

    WB analysis of HeLa using 20439-1-AP (same clone as 20439-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 20439-1-AP (CLK1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20439-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of COLO 320 cells using CLK1 Polyclonal antibody (20439-1-AP)

    WB analysis of COLO 320 using 20439-1-AP (same clone as 20439-1-PBS)

    COLO 320 cells were subjected to SDS PAGE followed by western blot with 20439-1-AP (CLK1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20439-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of COLO 320 cells using CLK1 Polyclonal antibody (20439-1-AP)

    IP experiment of COLO 320 using 20439-1-AP (same clone as 20439-1-PBS)

    IP result of anti-CLK1 (IP:20439-1-AP, 4ug; Detection:20439-1-AP 1:300) with COLO 320 cells lysate 2000ug. This data was developed using the same antibody clone with 20439-1-PBS in a different storage buffer formulation.

CLK1 Polyclonal antibody, PBS Only

CLK1 Polyclonal Antibody for WB, IP, Indirect ELISA
Cat No. 20439-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IP, Indirect ELISA

Synonyms

CDC-like kinase 1, CLK, EC:2.7.12.1, STY

Formulation:  PBS Only
PBS, Azide, Glycerol
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

ご購入について

国内販売は「コスモ・バイオ株式会社」を通じて行っております。お見積り・ご注文はお近くの販売代理店へご連絡ください。

国内在庫・納期について

約2万点のプロテインテック製品をコスモバイオ社物流センター（国内）に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。

保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

20439-1-PBS targets CLK1 in WB, IP, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag14214

Product name: Recombinant human CLK1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-143 aa of BC031549

Sequence: MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVED

相同性解析による交差性が予測される生物種
Full Name CDC-like kinase 1
Calculated molecular weight 484 aa, 57 kDa
Observed molecular weight 62 kDa
GenBank accession numberBC031549
Gene Symbol CLK1
Gene ID (NCBI) 1195
RRIDAB_2878686
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDP49759
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

CLK1 (CDC-like kinase 1) is the dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. It phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. It can phosphorylate: SRSF1, SRSF3 and PTPN1 (PMID: 10480872; 19168442). It also regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (PMID: 19168442). Elevated CLK1 activity is frequently detected in cancers, where it alters splice isoform balance to promote proliferation, invasion and chemoresistance, making it an emerging therapeutic target.

||
New chat

Able™

正在加载，请稍候...