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Validation Data Gallery

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  • Western Blot (WB) analysis of hTERT-RPE1 cells using CLCC1 Monoclonal antibody (68853-7-Ig)

    WB analysis of hTERT-RPE1 using 68853-7-Ig (same clone as 68853-7-PBS)

    hTERT-RPE1 cells were subjected to SDS PAGE followed by western blot with 68853-7-Ig (CLCC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68853-7-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of COLO 320 cells using CLCC1 Monoclonal antibody (68853-7-Ig)

    WB analysis of COLO 320 using 68853-7-Ig (same clone as 68853-7-PBS)

    COLO 320 cells were subjected to SDS PAGE followed by western blot with 68853-7-Ig (CLCC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68853-7-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using CLCC1 Monoclonal antibody (68853-7-Ig)

    WB analysis using 68853-7-Ig (same clone as 68853-7-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68853-7-Ig (CLCC1 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68853-7-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using CLCC1 Monoclonal antibody (68853-7-Ig)

    WB analysis using 68853-7-Ig (same clone as 68853-7-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68853-7-Ig (CLCC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68853-7-PBS in a different storage buffer formulation.

CLCC1 Monoclonal antibody, PBS Only

CLCC1 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 68853-7-PBS
Clone No.3C4B4

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

Mid-1-related chloride channel protein 1, MCLC, KIAA0761, Chloride channel CLIC-like protein 1, chloride channel CLIC like 1

Formulation:  PBS Only
PBS, Azide, Glycerol
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

68853-7-PBS targets CLCC1 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen

CatNo: Ag24682

Product name: Recombinant human CLCC1 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 315-501 aa of BC002939

Sequence: GPESEPPQALRPRDRRRQEEIDYRPDGGAGDADFHYRGQMGPTEQGPYAKTYEGRREILRERDVDLRFQTGNKSPEVLRAFDVPDAEAREHPTVVPSHKSPVLDTKPKETGGILGEGTPKESSTESSQSAKPVSGQDTSGNTEGSPAAEKAQLKSEAAGSPDQGSTYSPARGVAGPRGQDPVSSPCG

相同性解析による交差性が予測される生物種
Full Name chloride channel CLIC-like 1
Calculated molecular weight 551 aa, 62 kDa
Observed molecular weight 50-60 kDa
GenBank accession numberBC002939
Gene Symbol CLCC1
Gene ID (NCBI) 23155
Conjugate Unconjugated
Form
FormLiquid
Purification MethodProtein G purification
UNIPROT IDQ96S66
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

CLCC1, also known as MCLC, is a transmembrane protein that localizes to intracellular compartments, including endoplasmic reticulum (ER), and it functions as a chloride channel (PMID: 11279057). It has been shown that loss of CLCC1 results in ER Stress, misfolded protein accumulation, and neurodegeneration (PMID: 25698737). CLCC1 forms homomultimer in the ER membrane and is a pore-forming component of an anion channel. Studies found that disruption of ER ion homeostasis maintained by CLCC1 is one of the causes of neurodegenerative diseases, such as ALS (amyotrophic lateral sclerosis) (PMID: 37142673).

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