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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using CAAP1 Polyclonal antibody (26213-1-AP)

    WB analysis using 26213-1-AP (same clone as 26213-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 26213-1-AP (C9orf82 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 26213-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of A431 cells using CAAP1 Polyclonal antibody (26213-1-AP)

    IP experiment of A431 using 26213-1-AP (same clone as 26213-1-PBS)

    IP result of anti-C9orf82 (IP:26213-1-AP, 4ug; Detection:26213-1-AP 1:3000) with A431 cells lysate 800 ug. This data was developed using the same antibody clone with 26213-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human liver tissue using CAAP1 Polyclonal antibody (26213-1-AP)

    IHC staining of human liver using 26213-1-AP (same clone as 26213-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 26213-1-AP (CAAP1 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26213-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human liver tissue using CAAP1 Polyclonal antibody (26213-1-AP)

    IHC staining of human liver using 26213-1-AP (same clone as 26213-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 26213-1-AP (CAAP1 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 26213-1-PBS in a different storage buffer formulation.

CAAP1 Polyclonal antibody, PBS Only

CAAP1 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 26213-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, IP, Indirect ELISA

Synonyms

C9orf82, CAAP, Caspase activity and apoptosis inhibitor 1, Conserved anti-apoptotic protein, RP11 337A23.1

Formulation:  PBS Only
PBS, Azide, Glycerol
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

26213-1-PBS targets CAAP1 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag23850

Product name: Recombinant human C9orf82 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-361 aa of BC014658

Sequence: MTGKKSSREKRRKRSSQEAAAALAAPDIVPALASGSSGSTSGCGSAGGCGSVSCCGNANFSGSVTGGGSGGSCWGGSSVERSERRKRRSTDSSSVSGSLQQETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNCSIEEIKKLCQEQLELLSKKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQQDICIDSASSVRENKQPEGLELKQGKGEDSDVLSINADAYDSDIEGPCNEEAAAPEAPENTVQSEAGQIDDLEKDIEKSVNEILGLAESSPNEPKAATLAVPPPEDVQPSAQQLELLELEMRARAIKALMKAGDIKKPA

相同性解析による交差性が予測される生物種
Full Name chromosome 9 open reading frame 82
Observed molecular weight47-55 kDa
GenBank accession numberBC014658
Gene Symbol C9orf82
Gene ID (NCBI) 79886
RRIDAB_3742173
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9H8G2
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

CAAP1 (Caspase Activity and Apoptosis Inhibitor 1), also known as C9orf82, is an evolutionarily conserved anti-apoptotic protein. It inhibits apoptosis by interfering with the activation of caspase-10, thereby blocking the feedback amplification loop of caspase-3/9 in the mitochondrial apoptotic pathway. Recent studies have revealed that CAAP1 plays a dual role in the regulation of autophagy, balancing the processes of autophagy and apoptosis. In tumor biology, the expression level of CAAP1 is associated with chemotherapy resistance in various cancers, making it a potential prognostic biomarker. In addition, CAAP1 is involved in neuroprotective mechanisms and plays an important role in hypoxic-ischemic brain injury by regulating neuronal apoptosis. Its expression is finely regulated by non-coding RNA networks, including MKL1/miR-5100 and miR-184-5p. (PMID: 30629682)

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