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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

SURVIVIN-Specific Polyclonal antibody

SURVIVIN-Specific Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

ELISA

Conjugate

Unconjugated

Cat no : 19119-1-AP

Synonyms

API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, BIRC5, EPR 1, IAP4, SURVIVIN

Validation Data Gallery

Applications:
  • WB analysis of HeLa using 19119-1-AP

    WB analysis of HeLa using 19119-1-AP

    HeLa cells were subjected to SDS PAGE followed by western blot with 19119-1-AP (SURVIVIN-Specific antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours.

  • IHC staining of human pancreas cancer using 19119-1-AP

    IHC staining of human pancreas cancer using 19119-1-AP

    Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 19119-1-AP (SURVIVIN-Specific Antibody) at dilution of 1:50 (under 10x lens).

    Ready-to-use IHC kits available with SURVIVIN antibody included
  • IHC staining of human pancreas cancer using 19119-1-AP

    IHC staining of human pancreas cancer using 19119-1-AP

    Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 19119-1-AP (SURVIVIN-Specific Antibody) at dilution of 1:50 (under 40x lens).

    Ready-to-use IHC kits available with SURVIVIN antibody included
  • IHC staining of human colon cancer using 19119-1-AP

    IHC staining of human colon cancer using 19119-1-AP

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 19119-1-AP (SURVIVIN-Specific Antibody) at dilution of 1:50 (under 10x lens).

    Ready-to-use IHC kits available with SURVIVIN antibody included
  • IHC staining of human colon cancer using 19119-1-AP

    IHC staining of human colon cancer using 19119-1-AP

    Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 19119-1-AP (SURVIVIN-Specific Antibody) at dilution of 1:50 (under 40x lens).

    Ready-to-use IHC kits available with SURVIVIN antibody included
  • IHC staining of human lung cancer using 19119-1-AP

    IHC staining of human lung cancer using 19119-1-AP

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 19119-1-AP (SURVIVIN-Specific Antibody) at dilution of 1:50 (under 10x lens).

    Ready-to-use IHC kits available with SURVIVIN antibody included
  • IHC staining of human lung cancer using 19119-1-AP

    IHC staining of human lung cancer using 19119-1-AP

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 19119-1-AP (SURVIVIN-Specific Antibody) at dilution of 1:50 (under 40x lens).

    Ready-to-use IHC kits available with SURVIVIN antibody included
  • IF Staining of HeLa using 19119-1-AP

    IF Staining of HeLa using 19119-1-AP

    Immunofluorescent analysis of HeLa cells using 19119-1-AP (SURVIVIN-Specific antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Tested Applications

Planning an IHC experiment? We recommend our IHCeasy SURVIVIN Ready-To-Use IHC Kit. SURVIVIN primary antibody included.

Recommended dilution

ApplicationDilution
Sample-dependent, check data in validation data gallery

Product Information

19119-1-AP targets SURVIVIN-Specific in ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide 相同性解析による交差性が予測される生物種
Full Name baculoviral IAP repeat-containing 5
Calculated molecular weight 18 kDa
GenBank accession numberNM_001168
Gene symbol BIRC5
Gene ID (NCBI) 332
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

BIRC5, also named as API4 and IAP4, is a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Isoforms 2 and 3 do not appear to play vital roles in mitosis. Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform. The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. BIRC5 may play a role in neoplasia and counteract a default induction of apoptosis in G2/M phase. The antibody can recognize all these isoforms of BIRC5.