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Validation Data Gallery

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  • Western Blot (WB) analysis of HeLa cells using BCCIP Polyclonal antibody (16043-1-AP)

    WB analysis of HeLa using 16043-1-AP (same clone as 16043-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 16043-1-AP (BCCIP antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16043-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of A549 cells using BCCIP Polyclonal antibody (16043-1-AP)

    WB analysis of A549 using 16043-1-AP (same clone as 16043-1-PBS)

    A549 cells were subjected to SDS PAGE followed by western blot with 16043-1-AP (BCCIP antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16043-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of HeLa cells using BCCIP Polyclonal antibody (16043-1-AP)

    IP experiment of HeLa using 16043-1-AP (same clone as 16043-1-PBS)

    IP result of anti-BCCIP (IP:16043-1-AP, 4ug; Detection:16043-1-AP 1:800) with HeLa cells lysate 3200ug. This data was developed using the same antibody clone with 16043-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HeLa cells using BCCIP Polyclonal antibody (16043-1-AP)

    IF Staining of HeLa using 16043-1-AP (same clone as 16043-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed HeLa cells using BCCIP antibody (16043-1-AP) at dilution of 1:800 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 16043-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

BCCIP Polyclonal antibody, PBS Only

BCCIP Polyclonal Antibody for WB, IF/ICC, IP, Indirect ELISA
Cat No. 16043-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IF/ICC, IP, Indirect ELISA

Synonyms

TOK1, TOK 1, Protein TOK-1, Protein TOK 1, P21- and CDK-associated protein 1

Formulation:  PBS Only
PBS, Azide, Glycerol
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

16043-1-PBS targets BCCIP in WB, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag8934

Product name: Recombinant human BCCIP protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-314 aa of BC009771

Sequence: MASRSKRRAVESGVPQPPDPPVQRDEEEEKEVENEDEDDDDSDKEKDEEDEVIDEEVNIEFEAYSLSDNDYDGIKKLLQQLFLKAPVNTAELTDLLIQQNHIGSVIKQTDVSEDSNDDMDEDEVFGFISLLNLTERKGTQCVEQIQELVLRFCEKNCEKSMVEQLDKFLNDTTKPVGLLLSERFINVPPQIALPMYQQLQKELAGAHRTNKPCGKCYFYLLISKTFVEAEKNNSKKKPSNKKKAALMFANAEEEFFYEKAILKFNYSVQEESDTCLGGKWSFDDVPMTPLRTVMLIPGDKMNEIMDKLKEYLSV

相同性解析による交差性が予測される生物種
Full Name BRCA2 and CDKN1A interacting protein
Calculated molecular weight 314 aa, 36 kDa
Observed molecular weight 50-58 kDa
GenBank accession numberBC009771
Gene Symbol BCCIP
Gene ID (NCBI) 56647
RRIDAB_2063712
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9P287
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

BCCIP (or TOK1) is isolated as a BRCA2- and CDKN1A (p21)-interacting protein and is implicated in homologous recombination (HR) pathway and inhibition of DNA replication stress. BCCIP is an evolutionarily conserved nuclear protein with multiple interacting domains. BCCIP deficiency in mice impaired embryonic and postnatal neural development, causing severe ataxia, cerebral and cerebellar defects, and microcephaly, which are associated with spontaneous DNA damage and subsequent cell death in the proliferative cell populations of the neural system during embryogenesis. BCCIP is essential for maintaining the transactivation activity of wild type p53 suggesting a potential role of BCCIP in cancer etiology.

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