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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using BASP1 Polyclonal antibody (14880-1-AP)

    WB analysis using 14880-1-AP (same clone as 14880-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 14880-1-AP (BASP1 antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14880-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse brain tissue using BASP1 Polyclonal antibody (14880-1-AP)

    IHC staining of mouse brain using 14880-1-AP (same clone as 14880-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 14880-1-AP (BASP1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14880-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human skin cancer tissue using BASP1 Polyclonal antibody (14880-1-AP)

    IHC staining of human skin cancer using 14880-1-AP (same clone as 14880-1-PBS)

    Immunohistochemical analysis of paraffin-embedded skin cancer slide using 14880-1-AP (BASP1 antibody) at dilution of 1:1600 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14880-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human skin cancer tissue using BASP1 Polyclonal antibody (14880-1-AP)

    IHC staining of human skin cancer using 14880-1-AP (same clone as 14880-1-PBS)

    Immunohistochemical analysis of paraffin-embedded skin cancer slide using 14880-1-AP (BASP1 antibody) at dilution of 1:1600 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 14880-1-PBS in a different storage buffer formulation.

BASP1 Polyclonal antibody, PBS Only

BASP1 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 14880-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Synonyms

22 kDa neuronal tissue-enriched acidic protein, Brain acid soluble protein 1, CAP 23, CAP23, NAP 22

Formulation:  PBS Only
PBS, Azide, Glycerol
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

14880-1-PBS targets BASP1 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag6653

Product name: Recombinant human BASP1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-227 aa of BC000518

Sequence: MGGKLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEPKKTGAPAAPAAQETKSDGAPASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEAPAANSDQTVTVKE

相同性解析による交差性が予測される生物種
Full Name brain abundant, membrane attached signal protein 1
Calculated molecular weight 23 kDa
Observed molecular weight 55-60 kDa
GenBank accession numberBC000518
Gene Symbol BASP1
Gene ID (NCBI) 10409
RRIDAB_3085444
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDP80723
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

BASP1 (brain acid-soluble protein 1), also known as NAP22 or CAP-23, is an evolutionarily conserved intrinsically disordered protein that participates in cell signaling, migration, apoptosis, and gene transcription. It is highly expressed in the nervous system and plays roles in neurodevelopment, synaptic function, and nerve regeneration. BASP1 exhibits context-dependent functions in disease: it acts as a tumor suppressor in gastric cancer by inhibiting the Wnt/β-catenin pathway and in acute myeloid leukemia, while promoting atherosclerosis via vascular smooth muscle cell proliferation and inflammation. It has emerged as a promising therapeutic target and diagnostic biomarker. (PMID: 33426068; 41415108; 33015061)

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