Alpha-1-Antitrypsin Recombinant antibody
Alpha-1-Antitrypsin Recombinant Antibody for WB, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
Human
Applications
WB, ELISA
Conjugate
Unconjugated
CloneNo.
230109A8
Cat no : 82918-1-RR
Synonyms
Validation Data Gallery
Tested Applications
Positive WB detected in | human liver tissue, human heart tissue, human saliva, human placenta tissue, human urine |
Recommended dilution
Application | Dilution |
---|---|
Western Blot (WB) | WB : 1:5000-1:50000 |
Sample-dependent, check data in validation data gallery |
Product Information
82918-1-RR targets Alpha-1-Antitrypsin in WB, ELISA applications and shows reactivity with Human samples.
Tested Reactivity | Human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | Alpha-1-Antitrypsin fusion protein Ag9369 相同性解析による交差性が予測される生物種 |
Full Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
Calculated molecular weight | 418 aa, 47 kDa |
Observed molecular weight | 47 kDa |
GenBank accession number | BC015642 |
Gene symbol | SERPINA1 |
Gene ID (NCBI) | 5265 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
SERPINA1 is the gene for a protein called alpha-1-antitrypsin (AAT), which is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes, with smaller amountssynthesized by intestinal epithelial cells, neutrophils, pulmonary alveolar cells and macrophages. AAT is the most abundant, endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation, fibrinolysis, complement activation, apoptosis, reproduction, tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease.
Protocols
Product Specific Protocols | |
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WB protocol for Alpha-1-Antitrypsin antibody 82918-1-RR | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |