Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
27265-1-PBS targets Ataxin-1 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag26099 Product name: Recombinant human ATXN1 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 301-400 aa of NM_000332 Sequence: VPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQA 相同性解析による交差性が予測される生物種 |
| Full Name | ataxin 1 |
| Calculated molecular weight | 87 kDa |
| Observed molecular weight | 100 kDa |
| GenBank accession number | NM_000332 |
| Gene Symbol | ATXN1 |
| Gene ID (NCBI) | 6310 |
| RRID | AB_3742225 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P54253 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
Ataxin-1 (ATXN1) is a protein involved in transcriptional regulation and RNA binding. It is a transcriptional repressor that interacts with multiple transcription factors and is associated with large protein complexes. ATXN1 is also involved in the regulation of alternative splicing, as demonstrated by its ability to regulate the splicing of several minigenes. The protein is crucial for normal cerebellar function and is implicated in the pathogenesis of spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disorder caused by the expansion of a polyglutamine tract in ATXN1 (PMID: 21475249; 20628574).