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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using ARHGEF11 Recombinant antibody (84149-4-RR)

    WB analysis using 84149-4-RR (same clone as 84149-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84149-4-RR (ARHGEF11 antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84149-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84149-4-PBS

    Affinity and Kinetic Characterization of 84149-4-PBS

    Biolayer interferometry (BLl) kinetic assay of 84149-4-PBS against Human ARHGEF11 was performed. The affinity constant is 0.707 nM.

  • Affinity and Kinetic Characterization of 84149-4-RR

    Affinity and Kinetic Characterization of 84149-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84149-4-RR against Human ARHGEF11 were performed. The affinity constant is 0.742 nM.

ARHGEF11 Recombinant monoclonal antibody, PBS Only

ARHGEF11 Uni-rAb® Recombinant Antibody for WB, Indirect ELISA
Cat No. 84149-4-PBS
Clone No.241427G2

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

241427G2, GTRAP48, KIAA0380, PDZ RHOGEF

Formulation:  PBS Only
PBS, Azide, Glycerol
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

84149-4-PBS targets ARHGEF11 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen

CatNo: Ag33104

Product name: Recombinant human ARHGEF11 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1223-1522 aa of

Sequence: ETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPCPEDGSDAPLEDSTADAAASPGP

相同性解析による交差性が予測される生物種
Full Name Rho guanine nucleotide exchange factor (GEF) 11
Calculated molecular weight168 kDa
Observed molecular weight220 kDa
Gene Symbol ARHGEF11
Gene ID (NCBI) 9826
Conjugate Unconjugated
Form
FormLiquid
Purification MethodProtein A purification
UNIPROT IDO15085
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

ARHGEF11 (Rho guanine nucleotide exchange factor 11) is a specific guanine nucleotide exchange factor (GEF) for RhoA, which is a critical regulator of actin cytoskeleton dynamics and organization of dendritic spines and inhibitor of spine maintenance (PMID: 28036092). ARHGEF11 has been proven to promote tumor metastasis in glioblastoma and ovarian carcinoma (PMID: 33122451).

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