Validation Data Gallery
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Tested Applications
| Positive WB detected in | Neuro-2a cells, SH-SY5Y cells |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:2000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Published Applications
| KD/KO | See 1 publications below |
| WB | See 4 publications below |
| IF | See 2 publications below |
Product Information
55065-1-AP targets ADCY8 in WB, IF, ELISA applications and shows reactivity with human, mouse samples.
| Tested Reactivity | human, mouse |
| Cited Reactivity | human, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
Peptide 相同性解析による交差性が予測される生物種 |
| Full Name | adenylate cyclase 8 (brain) |
| Calculated molecular weight | 140 kDa |
| Observed molecular weight | 140-150 kDa |
| GenBank accession number | NM_001115 |
| Gene Symbol | ADCY8 |
| Gene ID (NCBI) | 114 |
| RRID | AB_10859258 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P40145 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -20°C. Aliquoting is unnecessary for -20oC storage. |
Background Information
ADCY8 Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence. The antibody is specific to ADCY8.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for ADCY8 antibody 55065-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
Function (Oxf) AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca2+ Channels. | ||
Nat Commun A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction.
| ||
Mol Ther Inhibition of adenylyl cyclase 8 prevents the upregulation of Orai1 channel which improves cardiac function after myocardial infarction | ||
Int J Mol Sci Combined Proteomic and Metabolomic Analysis Reveals Comprehensive Regulation of Somatostatin DNA Vaccine in Goats |
