MRP2 Polyclonal antibody
MRP2 Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
ELISA
Conjugate
Unconjugated
Cat no : 18702-1-AP
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
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Sample-dependent, check data in validation data gallery |
Product Information
18702-1-AP targets MRP2 in ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Peptide 相同性解析による交差性が予測される生物種 |
Full Name | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
Calculated molecular weight | 174 kDa |
GenBank accession number | BC136419 |
Gene symbol | ABCC2 |
Gene ID (NCBI) | 1244 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
ABCC2, also named as CMOAT, CMOAT1, CMRP and MRP2, is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABCC2 is a member of the MRP subfamily which is involved in multi-drug resistance. It is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. The substrates of ABCC2 include anticancer drugs such as vinblastine; therefore, it appears to contribute to drug resistance in mammalian cells. Several different mutations have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.