Recombinant Mouse TREML2 protein (rFc Tag)
Species
Mouse
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg7510
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Mouse TREML2 protein His25-Ala270 (Accession# Q2LA85) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 328833 |
| Accession | Q2LA85 |
| PredictedSize | 53.1 kDa |
| SDS-PAGE | 80-100 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Triggering receptor expressed on myeloid cells-like protein 2 (TREML2) is a cell-surface receptor participating in innate and adaptive immune responses. It functions as a counter-receptor for CD276, and its binding to CD276 on T cells potentiates T-cell activation. Upregulating TREML2 represents a potential novel therapeutic strategy to alleviate doxorubicin resistance in acute myeloid leukemia.
References:
1. Allcock, Richard J N et al. European journal of immunology vol. 33,2 (2003): 567-77. 2. Hashiguchi, Masaaki et al. Proceedings of the National Academy of Sciences of the United States of America vol. 105,30 (2008): 10495-500. 3. Zhang, Xin et al. Blood science (Baltimore, Md.) vol. 7,2 (2025): e00223.