Recombinant Human RRAS protein (rFc Tag)
Species
Human
Purity
>85 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg6612
Validation Data Gallery
Product Information
| Purity | >85 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human RRAS protein Asp23-Ser201 (Accession# P10301) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 6237 |
| Accession | P10301 |
| PredictedSize | 45.5 kDa |
| SDS-PAGE | 44-53 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Ras-related protein R-Ras2 (RRAS2) is also named TC21 and Teratocarcinoma oncogene. The RRAS2 member of the RAS-related subfamily, also known as TC21, is a close relative of the classic RAS GTPases (PMID: 3898776). RRAS2, a member of the R-Ras subfamily of Ras-like low-molecular-weight GTPases, is located in the plasma membrane and functions as a signal transducer (PMID: 38601074). RRAS2 is GTP-binding protein with GTPase activity, involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes (PMID: 31130282).
References:
1. Colicelli, John. Science's STKE 2004.250 (2004): re13-re13. 2. Pfeil, Alexander J., et al. Clinical Cancer Research (2026). 3. Xiao, Ruowen, et al. Translational Cancer Research 8.2 (2019): 664. 4. Flex, Elisabetta, et al. Human molecular genetics 23.16 (2014): 4315-4327. 5. Miller, John P., et al. PLoS genetics 8.11 (2012): e1003042.