Recombinant Human XPNPEP2 protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg6084
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human XPNPEP2 protein His22-Ala649 (Accession# O43895) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 7512 |
| Accession | O43895 |
| PredictedSize | 96.3 kDa |
| SDS-PAGE | 90-120 kDa , reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
XPNPEP2 (also known as aminopeptidase P or APP2) is a membrane-bound metalloprotease that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, for example, Arg-Pro-Pro. It is a proline hydrolytic enzyme that hydrolyzes several biologically active peptides and causes a loss of substrate activity. XPNPEP2 expression was significantly upregulated in cervical cancer tissues compared with normal cervical tissues and cervical intraepithelial neoplasm tissues.
References:
1.Cheng, Teng et al. Tumour Biol. 2017;39(7):1010428317717122. 2.Sprinkle, T J et al. Genomics vol. 50,1 (1998): 114-6.