Recombinant Human MINP1 protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg6070
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human MINP1 protein Ser31-Leu487 (Accession# Q9UNW1) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 9562 |
| Accession | Q9UNW1 |
| PredictedSize | 77.7 kDa |
| SDS-PAGE | 70-90 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
MINPP1 (multiple inositol-polyphosphate phosphatase 1), also known as MIPP and MINPP2, is an enzyme that catalyzes the removal of the 3-phosphate group from inositol phosphate substrates. It plays a crucial role in the metabolism of inositol polyphosphates, which are important second messengers in cellular signaling pathways. MINPP1 has been implicated in various diseases, including certain types of cancer, where its expression levels may be associated with tumor progression and differentiation.
References:
1. Ucuncu, Ekin et al. Nature communications vol. 11,1 (2020): 6087. 2. Windhorst, Sabine et al. The Biochemical journal vol. 450,1 (2013): 115-25. 3. Appelhof, Bart et al. European journal of human genetics : EJHG vol. 29,3 (2021): 411-421.