Recombinant Human Cadherin-6 protein (rFc Tag)
Species
Human
Purity
>80 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg5864
Validation Data Gallery
Product Information
| Purity | >80 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human Cadherin-6 protein Thr19-Ala615 (Accession# P55285-1) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 1004 |
| Accession | P55285-1 |
| PredictedSize | 92.0 kDa |
| SDS-PAGE | 98-125 kDa , reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Cadherin-6 (CDH6/K-cadherin) is a type I transmembrane glycoprotein of the cadherin superfamily, mediating Ca²⁺-dependent homophilic cell adhesion. It is critical for embryonic kidney morphogenesis, neuronal migration, and placental development. CDH6 is overexpressed in ovarian, renal, and gastric cancers, driving tumor progression and metastasis. It is a validated ADC drug target; the CDH6-targeted ADC R-DXd is in phase II/III trials for platinum-resistant ovarian cancer.
References:
1. Shimazui, T et al. European urology vol. 38,3 (2000): 331-8. 2. Osterhout, Jessica A et al. Neuron vol. 71,4 (2011): 632-9.