Recombinant Human Neogenin protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg5518
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human Neogenin protein Ala34-Leu1105 (Accession# Q92859-1) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 4756 |
| Accession | Q92859-1 |
| PredictedSize | 143.2 kDa |
| SDS-PAGE | 130-200 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Neogenin, also named as IGDCC2 and NEO1, belongs to the immunoglobulin superfamily and DCC(deleted in colorectal cancer) family. NEO1 may be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. NEO1 may also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues.
References:
1. Xia, Xueli et al. Cytokine & growth factor reviews vol. 64, (2022): 46-56. 2. Mancino, Mario et al.Cancer research vol. 69,5 (2009): 1717-21. 3. Villanueva, Andrea A et al.Cell adhesion & migration vol. 15,1 (2021): 58-73.