Recombinant Human SAA protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg4687
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human SAA protein Arg19-Tyr122 (Accession# P0DJI8) with a rabbit IgG Fc tag at the N-terminus. |
| GeneID | 6288 |
| Accession | P0DJI8 |
| PredictedSize | 38.5 kDa |
| SDS-PAGE | 37-45 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Human SAA proteins are a group of apolipoproteins mainly found in the high density lipoprotein (HDL) portion of plasma. The serum amyloid A (SAA) protein is an acute phase apolipoprotein reactant produced mainly by hepatocytes and under the regulation of inflammatory cytokines. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA2 protein.
References:
1. Lundmark K, et al. (2002) Proc Natl Acad Sci U S A. 99(10):6979-6984. 2. Baba S, et al. (1992) Biochim Biophys Acta. 1180(2):195-200. 3. Webb NR. (2021) Curr Atheroscler Rep. 23(2):7. 4. Abouelasrar Salama S, et al. (2023) Front Endocrinol (Lausanne). 14:1119227.