Recombinant Human GHR protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg3027
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human GHR protein Ala27-Tyr264 (Accession# P10912-1) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 2690 |
| Accession | P10912-1 |
| PredictedSize | 53.2 kDa |
| SDS-PAGE | 60-85 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
GH is a peptide hormone with many pleiotropic actions, including the regulation of metabolism, postnatal growth, cognition, immune, cardiac and renal systems and gut function. GH receptor (GHR) is a member of the cytokine receptor family. GHR is widely expressed and is detected as early as in a two-cell embryo stage. Mutations in GHR gene have been associated with Laron syndrome, also known as the GH insensitivity syndrome (GHIS), a disorder characterized by short stature
References:
1. Waters, Michael J. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society vol. 28 (2016): 6-10. 2. Guevara-Aguirre, Jaime et al. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society vol. 38 (2018): 34-38. 3. Yan, Hong-Zhu et al. Journal of cellular and molecular medicine vol. 25,5 (2021): 2450-2458.