Recombinant Mouse IL-17C protein (rFc Tag)
Species
Mouse
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg2840
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | CHO-derived Mouse IL-17C protein His15-Gln194 (Accession# Q8K4C5) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 234836 |
| Accession | Q8K4C5 |
| PredictedSize | 45.7 kDa |
| SDS-PAGE | 45-53 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
IL-17C is a member of the IL-17 cytokine family, was cloned from a human fetal kidney library in 2000 . The IL-17 family comprises at least 6 proinflammatory cytokines that share a conserved cystine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17C is selectively induced in epithelia by bacterial challenge and inflammatory stimuli . IL-17RE is a receptor specific to IL-17C and has an essential role in host mucosal defense against infection.
References:
1.Chen, J et al. Proceedings of the National Academy of Sciences of the United States of America vol. 97,2 (2000): 773-8. 2.Kolls, Jay K et al. Immunity vol. 21,4 (2004): 467-76. 3.Hymowitz, S G et al. The EMBO journal vol. 20,19 (2001): 5332-41. 4.Ramirez-Carrozzi, Vladimir et al. Nature immunology vol. 12,12 (2011): 1159-66. 5.Shi, Peiqing et al. Nature immunology vol. 12,12 (2011): 1151-8.