Recombinant Human IL-13RA2 protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg2579
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | CHO-derived Human IL-13RA2 protein Asp27-Arg343 (Accession# Q14627) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 3598 |
| Accession | Q14627 |
| PredictedSize | 63.4 kDa |
| SDS-PAGE | 65-80 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
IL-13RA2 is an inhibitory decoy receptor with a high affinity for IL-13 and diminishes its certain effector functions. IL-13/IL-13RA2 signaling has been repeatedly reported as an excellent therapeutic target for multiple types of cancers. Although many physiological and pathological roles of IL-13/IL-13RA2 signaling transduction have been described, its biological roles and regulatory mechanisms in CSCs remain largely unknown.
References:
1. Hallett, Miranda A et al. Cancer research vol. 72,24 (2012): 6338-43. 2. He, Baoyu et al. Genes & diseases vol. 11,1 495-508. 23 Apr. 2023.
