Validation Data Gallery
Tested Applications
| Positive WB detected in | mouse brain tissue, rat brain tissue |
This antibody is equivalent to Ser1756 in rat.
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:5000-1:50000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
87294-1-RR targets Phospho-ITPR1 (Ser1764) in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
Peptide 相同性解析による交差性が予測される生物種 |
| Full Name | inositol 1,4,5-triphosphate receptor, type 1 |
| Calculated molecular weight | 314 kDa |
| Observed molecular weight | 320 kDa |
| GenBank accession number | NM_001378452 |
| Gene Symbol | ITPR1 |
| Gene ID (NCBI) | 3708 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q14643 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
ITPR1, also named as INSP3R1 and IP3R, belongs to the InsP3 receptor family. Phospho-ITPR1 (Thr853) is a phosphorylated form of the inositol-trisphosphate receptor type 1 (ITPR1) protein at threonine residue 853. This phosphorylation site is involved in the regulation of calcium signaling pathways within cells. The specific function and role of Thr853 phosphorylation in ITPR1's activity are not detailed in the provided resources, but phosphorylation events on ITPR1 are known to influence its function, which affects calcium release from the endoplasmic reticulum. Calcium signaling is critical for various cellular processes, including muscle contraction, neurotransmitter release, and cellular division. This antibody is equivalent to Ser1756 in rat.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for Phospho-ITPR1 (Ser1764) antibody 87294-1-RR | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |