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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using Phospho-APP (Thr668) Polyclonal antibody (28788-1-AP)

    WB analysis using 28788-1-AP

    Non-treated and nocodazole treated SH-SY5Y cells were subjected to SDS PAGE followed by western blot with 28788-1-AP (Phospho-APP (Thr668) antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

Phospho-APP (Thr668) Polyclonal antibody

Phospho-APP (Thr668) Polyclonal Antibody for WB, ELISA
Cat No. 28788-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

WB, ELISA

Synonyms

A4, AAA, ABETA, ABPP, AD1, AICD 50, AICD 57, AICD 59, AID(50), AID(57), AID(59), Amyloid beta A4 protein, amyloid P, amyloid precursor protein, Amyloid-beta precursor protein, APP, APPI, beta Amyloid, CTFgamma, CVAP, Gamma CTF(50) C31, Phospho-APP (Thr668), PN II, PN2, PreA4, Protease nexin II, S APP alpha Soluble APP beta

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Positive WB detected innocodazole treated SH-SY5Y cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:3000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

28788-1-AP targets Phospho-APP (Thr668) in WB, ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

Peptide

相同性解析による交差性が予測される生物種
Full Name amyloid beta (A4) precursor protein
Observed molecular weight110 kDa
GenBank accession numberBC065529
Gene Symbol APP
Gene ID (NCBI) 351
RRIDAB_2918202
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDP05067
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Amyloid precursor protein (APP) is a membrane-spanning protein with a large extracellular domain and a much smaller intracellular domain(PMID: 25719338). APP is expressed in many tissues and concentrated in the synapses of neurons. The molecular weight of APP is 100-140 kDa due to the existence of several isoforms. The phosphorylation of APP at Thr668 is involved in the pathogenesis of Alzheimer's disease (AD). The Phospho-APP Thr668 form is neuron‐specific, highly expressed in dystrophic neurites and amyloid plaques of Alzheimer disease, and induces neurodegeneration(PMID: 27076121).

Protocols

Product Specific Protocols
WB protocol for Phospho-APP (Thr668) antibody 28788-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols