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  • KD/KO Validated

GSDMC Polyclonal antibody

GSDMC Polyclonal Antibody for WB, IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

Human and More (2)

Applications

WB, IHC, ELISA

Conjugate

Unconjugated

Cat no : 27630-1-AP

Synonyms

gasdermin C, GSDMC, MLZE



Tested Applications

Positive WB detected inHeLa cells, HepG2 cells
Positive IHC detected inhuman kidney tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:2000
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

27630-1-AP targets GSDMC in WB, IHC, ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen GSDMC fusion protein Ag26365
Full Name gasdermin C
Calculated Molecular Weight 58 kDa
Observed Molecular Weight ~60 kDa
GenBank Accession NumberNM_031415
Gene Symbol GSDMC
Gene ID (NCBI) 56169
RRIDAB_2880930
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Protocols

Product Specific Protocols
WB protocol for GSDMC antibody 27630-1-APDownload protocol
IHC protocol for GSDMC antibody 27630-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB

Immunity

Disruption of the endopeptidase ADAM10-Notch signaling axis leads to skin dysbiosis and innate lymphoid cell-mediated hair follicle destruction.

Authors - Keiko Sakamoto
humanWB,IHC

Nat Cell Biol

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.

Authors - Junwei Hou
  • KO Validated
humanWB,IHC

J Clin Invest

Gasdermin C sensitizes tumor cells to PARP inhibitor therapy in cancer models

Authors - Shuanglian Wang
humanIHC

Am J Cancer Res

Pyroptosis impacts the prognosis and treatment response in gastric cancer via immune system modulation.

Authors - Wanli Yang
mouseWB

Front Oncol

siRNAs Targeting Mouse-Specific lncRNA AA388235 Induce Human Tumor Cell Pyroptosis/Apoptosis.

Authors - Yan-Ru Chen
mouseWB

Exp Ther Med

Tetracaine hydrochloride induces macrophage pyroptosis through caspase‑1/11‑GSDMD signaling pathways

Authors - Ran Zhang