- Featured Product
- KD/KO Validated
SLC22A18 Polyclonal antibody
SLC22A18 Polyclonal Antibody for IP, WB,ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat
Applications
WB, IP, IHC,ELISA
Conjugate
Unconjugated
Cat no : 11646-2-AP
Synonyms
Validation Data Gallery
Tested Applications
| Positive WB detected in | mouse brain tissue, COLO 320 cells |
| Positive IP detected in | mouse brain tissue |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:4000 |
| Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| Sample-dependent, check data in validation data gallery | |
Published Applications
| KD/KO | See 1 publications below |
| WB | See 1 publications below |
| IHC | See 1 publications below |
Product Information
11646-2-AP targets SLC22A18 in WB, IP, IHC,ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | SLC22A18 fusion protein Ag2245 相同性解析による交差性が予測される生物種 |
| Full Name | solute carrier family 22, member 18 |
| Calculated molecular weight | 408 aa, 43 kDa |
| Observed molecular weight | 40-50 kDa |
| GenBank accession number | BC015571 |
| Gene symbol | SLC22A18 |
| Gene ID (NCBI) | 5002 |
| RRID | AB_2191146 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
SLC22A18 is a member of the family of polyspecific organic-cation transporters that localize at the apical membrane surface of renal proximal tubules. SLC22A18 is expressed at high levels in the kidney, liver, colon and in fetal renal proximal tubules and present at lower levels in heart, brain and lung. Defects in SLC22A18 are associated with breast and lung cancer and are the cause of rhabdomyosarcoma type 1, a malignant tumor derived from striated muscle. More recently, SLC22A18 has been shown to functions as a tumor suppressor in glioma and represents a candidate biomarker for long-term survival in this disease.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for SLC22A18 antibody 11646-2-AP | Download protocol |
| IP protocol for SLC22A18 antibody 11646-2-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
Int J Biol Macromol microRNA-137 functions as a tumor suppressor in human non-small cell lung cancer by targeting SLC22A18.
| ||
Hum Mol Genet Parent-of-origin tumorigenesis is mediated by an essential imprinted modifier in SDHD-linked paragangliomas: SLC22A18 and CDKN1C are candidate tumor modifiers. | ||
Cancer Epidemiol Low expression of SLC22A18 predicts poor survival outcome in patients with breast cancer after surgery. |
