SARS-CoV-2 Spike Recombinant antibody

SARS-CoV-2 Spike Recombinant Antibody for ELISA, Neutralization

Host / Isotype

Human / IgG1

Reactivity

Virus and More (2)

Applications

ELISA, Neutralization

Conjugate

Unconjugated

CloneNo.

AM002414

Cat no : 91349-PTG

Synonyms

SARS-CoV-2, SARS-CoV-2 Spike, Spike


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Tested Applications

Positive Neutralization detected inpseudotyped virus
Positive ELISA detected inSARS-CoV-2 Spike RBD protein

Recommended dilution

ApplicationDilution
Sample dependent. To be determined by the end user.

Note: Proteintech is partnering with Active Motif to bring these cutting-edge, patient derived antibodies to our customers during this important time for COVID-19 research.

Product Information

91349-PTG targets SARS-CoV-2 Spike in ELISA, Neutralization applications and shows reactivity with Virus samples.

Tested Reactivity Virus
Cited Reactivityhuman, mouse
Host / Isotype Human / IgG1
Class Recombinant
Type Antibody
Immunogen Virus 相同性解析による交差性が予測される生物種
Full Name SARS-CoV-2 Spike Protein
Calculated molecular weight 141 kDa
GenBank accession numberNC_045512
Gene symbol SARS-COV-2
Gene ID (NCBI) 43740568
RRIDAB_2882951
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A Chromatography
Storage Buffer 140 mM Hepes, pH 7.5, 70 mM NaCl, 32mM NaOAc, 0.035% sodium azide, and 30% glycerol.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

COVID-19, which is short for coronavirus disease 2019, is the official name of the respiratory disease caused by infection with the novel coronavirus SARS-CoV-2. The virus that causes COVID-19 was named SARS-CoV-2 because it is a coronavirus genetically similar to, yet distinct from, the virus that caused the severe acute respiratory syndrome (SARS) outbreak in 2003. Studying the details of how this virus replicates and causes the disease will allow scientists and physicians to more rapidly develop fast and accurate methods of detection as well as to deploy therapeutic and vaccine strategies. This antibody was derived from COVID-19 patients who have cleared the virus. Patient serum IgG was sequenced and expressed as full-length IgG1 with human immunoglobulin heavy and light chains in mammalian 293 cells.

Publications

SpeciesApplicationTitle
mouse,humanNeutralization

Brain Behav Immun

Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 Variants of Concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer's disease

Authors - Michelle A Erickson